Tuesday, November 30, 2021

Sodium Hyaluronate vs Hyaluronic Acid: Differences, Benefits, & Uses

  • Sodium hyaluronate is the water-soluble salt form of hyaluronic acid, with similar capabilities, but deeper penetration 
  • This acid strengthens and thickens skin, smooths lines and wrinkles, and deeply hydrates 
  • It is available in multiple forms including skin care products, oral supplements and injections 

Hyaluronic acid is a natural component found in the body, and especially in the skin and connective tissues. It plays a critical role in attracting and maintaining skin’s moisture and as such, can be found in a wide range of skin care products. Sodium hyaluronate is a derivative of hyaluronic acid, and while both are similar in terms of benefits, there are key differences between the two.

What Is Sodium Hyaluronate? 

Sodium hyaluronate is a sodium salt that’s been synthesized to form smaller molecules for stability and oxidation resistance. This smaller molecule weight enables greater penetration and hydration at deeper levels. It is used in various forms for medicinal purposes as well as cosmetic skin care products. 

Skin care uses

Sodium hyaluronate is a key ingredient in multiple skin care products as it offers superior hydration by drawing in moisture to deeply hydrate and plump skin, and support collagen. 

Sodium hyaluronate can be found in a range of skin care products including serums, creams, gels, lotions and face washes. Different formulas are available for both the face and body. 

Other uses

In addition to skin care products, sodium hyaluronate also plays a role in treating several medical conditions, and is a primary ingredient in: 

  • Eye drops to treat dry eye; these drops act as a lubricant to moisten and soothe the eye
  • Joint injections to treat osteoarthritis, which occurs due to diminishing levels of  hyaluronic acid; this serves to lubricate and cushion joints, and reduce pain 
  • Intravesical treatment for interstitial cystitis; the solution coats the lining of the bladder to significantly reduce pain and improve quality of life

What’s the Difference Between Sodium Hyaluronate and Hyaluronic Acid? 

The main differences between sodium hyaluronate and hyaluronic acid is that the former is of smaller molecular weight and is water-soluble, allowing for deeper penetration and greater moisture retention.

While both provide similar benefits, this difference in molecular weight results in different mechanisms of action: sodium hyaluronate works deep within the layers of skin to hydrate while hyaluronic acid’s larger molecular size rests on the surface skin, and protects from water loss. Both support collagen via increased water retention which enables collagen to stretch without breaking.

Another difference is that sodium hyaluronate is less susceptible to oxidation, therefore it’s more stable.

Both are found within skin care products and prized for their hydrating, plumping and anti-aging benefits. For optimal results, you can also purchase skin care products that contain both sodium hyaluronate and hyaluronic acid; combined you can benefit from their individual characteristics.  

Sodium Hyaluronate Skin Care Benefits 

Sodium hyaluronate has multiple skin care benefits to plump up and revitalize skin, fight the signs of aging and support skin health.

Hydrates skin without clogging pores

Sodium hyaluronate boosts hydration in skin; its small molecular size enables it to penetrate within the deeper layers of skin between connective tissues, to effectively absorb and retain moisture. This action eliminates dryness and flaking, improves skin firmness, and reduces the look of fine lines and wrinkles. 

In one study examining the effects of creams, serums and lotions containing sodium hyaluronate, researchers found skin was significantly hydrated, smoothed, and elastic at 2, 4 and 8 weeks of treatment. The researchers confirmed the link between smaller molecular weight and greater hydration.

Lastly, sodium hyaluronate is nongreasy and noncomedogenic, so it won’t clog pores.

Smooths wrinkles and fine lines 

Sodium hyaluronate is a powerful humectant and can draw and retain moisture within the skin.

This increased moisture plumps the skin to smooth lines and wrinkles, helps prevent future lines from forming, and has been proven to be an effective anti-aging treatment. In one study examining several types of hyaluronic acid, researchers found the low-molecular weight of sodium hyaluronate improved both skin moisture and elasticity, and significantly reduced wrinkle depth.

A word about acne

Acne is notoriously difficult to treat, and many people with acne-prone skin are typically using one or more medicated skin care products to treat their symptoms. However an unwanted side effect of these treatments is dry and irritated skin.

When skin is too dry, it can overproduce oil in an attempt to compensate, resulting in excess oil and more breakouts. 

Sodium hyaluronate is considered safe for all skin types and since it is particularly gentle, can benefit acne-prone skin: it can counteract dryness by stabilizing moisture levels, and won’t add to the frequency of breakouts as it doesn’t block pores.

Sodium hyaluronate can be found in a range of skin care products including face washes, toners, serums, lotions, gels and creams; there are also undereye formulations. You can also choose among products that are designed for either facial or body use.

These skin care products can reduce dryness, redness and inflammation by increasing moisture and strengthening collagen. Healthy skin will appear more smoother and plumper; lines and wrinkles will be less pronounced.

Products that have sodium hyaluronate as the primary ingredient often have additional ingredients to achieve greater results such as:

  • Collagen, which also has water-binding properties
  • Glycerin to smooth an moisturize skin 
  • Hyaluronic acid, which works on the surface level to draw in moisture and prevent water loss
  • Vitamin A for its anti-aging and collagen-boosting benefits
  • Vitamin C for its anti-aging and wound-healing properties 
  • Vitamin E to nourish and protect the skin 

Powder form and oral supplements 

Sodium hyaluronate can also be purchased in powder form or as oral supplements and is considered safe for most people. You can target the same skin complaints and achieve additional benefits by using a systemic approach.

When used as a medicinal, it has been found to have antioxidant qualities, and play a significant role in immune responses and wound healing.  

Sodium Hyaluronate Safety and Side Effects 

Sodium hyaluronate is gentle and safe for most people to use but as with any new skin care product, it Is recommended to perform a patch-test first to identify an allergy. 

Side effects are few and include redness, warmth, pain and swelling. It has not yet been established if sodium hyaluronate can harm a fetus, therefore women who are pregnant or thinking of becoming pregnant should avoid use of all forms. 

Skin type profile

Sodium hyaluronate is safe and gentle for all skin types. However, if you notice any irritation or increased sensitivity after use, discontinue use.

Before you start using sodium hyaluronate, talk with your dermatologist to see if it’s right for you; this is particularly important if you’re already using prescribed topical treatments. 

Takeaway 

Sodium hyaluronate is the synthesized, salt form of hyaluronic acid. While it can provide the same benefits as hyaluronic acid, it does so via a different mechanism of action; by penetrating deeply within the skin due to its small molecular weight.

It can attract and bind to water, and maintain this moisture within the deeper layers of the skin. This hydrates the top layers, supports collagen and effectively firms and strengthens skin; this plumps the skin and improves the look of fine lines.

Depending on your needs, you can choose among a range of topical skin care products with sodium hyaluronate, or you can opt for powder form or oral supplements. You can also gain greater results by choosing a topical containing additional active ingredients such as glycerin to hydrate and smooth skin, and Vitamin E to nourish and protect.

Sources

  • Ang BCH, Sng JJ, Wang PXH, Htoon HM, Tong LHT. Sodium Hyaluronate in the Treatment of Dry Eye Syndrome: A Systematic Review and Meta-Analysis. Sci Rep. 2017 Aug 21;7(1):9013. doi:10.1038/s41598-017-08534-5
  • Salk RS, Chang TJ, D’Costa WF, Soomekh DJ, Grogan KA. Sodium hyaluronate in the treatment of osteoarthritis of the ankle: a controlled, randomized, double-blind pilot study. J Bone Joint Surg Am. 2006 Feb;88(2):295-302. doi:10.2106/JBJS.E.00193
  • Raymond I, Vasdev N, Ferguson J, Haskin M, Davis L, Hasan TS. The clinical effectiveness of intravesical sodium hyaluronate (cystistat®) in patients with interstitial cystitis/painful bladder syndrome and recurrent urinary tract infections. Curr Urol. 2012 Sep;6(2):93-8. doi:10.1159/000343517
  • Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008 May;144(5):666-72. doi:10.1001/archderm.144.5.666
  • Jegasothy SM, Zabolotniaia V, Bielfeldt S. Efficacy of a New Topical Nano-hyaluronic Acid in Humans. J Clin Aesthet Dermatol. 2014;7(3):27-29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970829/
  • Nobile V, Buonocore D, Michelotti A, Marzatico F. Anti-aging and filling efficacy of six types hyaluronic acid based dermo-cosmetic treatment: double blind, randomized clinical trial of efficacy and safety. J Cosmet Dermatol. 2014;13(4):277-287. doi:10.1111/jocd.12120
  • Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O. Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy. Skin Res Technol. 2016 Feb;22(1):55-62. doi:10.1111/srt.12228
  • Pechová V, Gajdziok J. Možnosti využití hyaluronátu sodného ve farmacii a medicíně [Possibilities of using sodium hyaluronate in pharmaceutical and medical fields]. Ceska Slov Farm. 2017 Summer;66(4):154-159. https://pubmed.ncbi.nlm.nih.gov/29351375/

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